Perbedaan Fraksi Ejeksi Ventrikel Kiri pada Pasien Penyakit Jantung Koroner dengan Jumlah Stenosis ?1 dan >1 yang Menjalani Tindakan Percutaneus Coronary Intervention
DOI:
https://doi.org/10.56742/nchat.v6i1.267Keywords:
Angiografi Koroner, Fraksi Ejeksi, Multivessel Disease, Penyakit Jantung Koroner, Stenosis KoronerAbstract
Penyakit jantung koroner (PJK) merupakan penyebab utama morbiditas dan mortalitas kardiovaskular. Derajat keparahan PJK, khususnya jumlah pembuluh koroner dengan stenosis signifikan, berperan penting dalam terjadinya disfungsi ventrikel kiri yang tercermin melalui penurunan fraksi ejeksi (EF). Penelitin ini bertujuan untuk menilai perbedaan rerata fraksi ejeksi ventrikel kiri pada pasien PJK berdasarkan jumlah pembuluh koroner dengan stenosis signifikan. Penelitian ini adalah observasional analitik dengan desain potong lintang ini menggunakan data rekam medis pasien PJK yang menjalani coronary angiography (CAG) dan/atau percutaneous coronary intervention (PCI) di RSU Bahteramas Provinsi Sulawesi Tenggara periode Januari–Desember 2022. Pasien dikelompokkan menjadi stenosis ?1 pembuluh (0–1 vessel) dan stenosis >1 pembuluh (2–3 vessel). Perbedaan rerata EF dianalisis menggunakan uji t tidak berpasangan. Sebanyak 96 pasien dianalisis, terdiri dari 61 pasien dengan stenosis ?1 pembuluh dan 35 pasien dengan stenosis >1 pembuluh. Rerata EF pada kelompok stenosis ?1 pembuluh adalah 46,5±14.0%, sedangkan pada kelompok stenosis >1 pembuluh sebesar 42.0±10.5%. Selisih rerata EF sebesar ?4.51% (95% CI ?9.52 hingga 0.50) dan tidak bermakna secara statistik (p=0.077). Meskipun demikian, terdapat kecenderungan penurunan EF seiring peningkatan jumlah pembuluh stenosis. Pasien PJK dengan stenosis >1 pembuluh cenderung memiliki fraksi ejeksi ventrikel kiri yang lebih rendah dibandingkan pasien dengan stenosis ?1 pembuluh.
References
World Health O. Cardiovascular Diseases (Cvds) Fact Sheet. 2025. [View at Publisher]
Global Burden of Cardiovascular D, Risks. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2022. Journal of the American College of Cardiology. 2023;82(24):2315-45. [View at Publisher] [Google Scholar]
Sliwa K, Viljoen CA, Stewart S, Miller MR, Prabhakaran D, Kumar RK, et al. Cardiovascular Disease in Low-and Middle-Income Countries Associated with Environmental Factors. 2024;31(6):688-97. [View at Publisher] [Google Scholar]
Mensah GA, Roth GA, Fuster VJJotACoC. The Global Burden of Cardiovascular Diseases and Risk Factors: 2020 and Beyond. American College of Cardiology Foundation Washington, DC; 2019. p. 2529-32. [View at Publisher] [Google Scholar]
Virani SS, Newby LK, Arnold SV, Bittner V, Brewer LC, Demeter SH, et al. 2023 Aha/Acc/Accp/Aspc/Nla/Pcna Guideline for the Management of Patients with Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. 2023;82(9):833-955. [View at Publisher] [Google Scholar]
Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 Aha/Acc/Hfsa Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. 2022;79(17):1757-80. [View at Publisher] [Google Scholar]
Wang W. Prognostic Implications of Left Ventricular Ejection Fraction Trajectory in Heart Failure. ESC Heart Failure. 2023;10(4):2765-77. [View at Publisher] [Google Scholar]
Xu J. Predictors and Mortality for Worsening Left Ventricular Ejection Fraction in Heart Failure with Preserved Ejection Fraction. Frontiers in Cardiovascular Medicine. 2022;9842345. [View at Publisher] [Google Scholar]
De Innocentiis C. Multivessel Coronary Artery Disease and Prognosis in Heart Failure with Reduced Ejection Fraction. European Journal of Heart Failure. 2021;23(8):1345-54. [View at Publisher] [Google Scholar]
Neumann FJ. 2018 Esc/Eacts Guidelines on Myocardial Revascularization. European Heart Journal. 2019;40(2):87-165. [View at Publisher] [Google Scholar]
Zhang Y. Five-Year Outcomes in Patients with Multivessel Coronary Artery Disease Undergoing Revascularization. Scientific Reports. 2024;1412345. [View at Publisher] [Google Scholar]
Li H. Predictive Factors for Multivessel Disease in Patients with Acute Coronary Syndrome: A Multicenter Study. BMC Cardiovascular Disorders. 2024;24765. [View at Publisher] [Google Scholar]
Singh R. Angiographic Characteristics of Coronary Artery Disease in Patients with Heart Failure. Journal of Cardiac Failure. 2025;31(10):1450-60. [View at Publisher] [Google Scholar]
Greene SJ, Butler J, Spertus JA, Hellkamp AS, Vaduganathan M, DeVore AD, et al. Comparison of New York Heart Association Class and Patient-Reported Outcomes for Heart Failure with Reduced Ejection Fraction. 2021;6(5):522-31. [View at Publisher] [Google Scholar]
Prasetyo DH, Nasution SA, Alwi I, Abdullah MJSMJ. Korelasi Kadar Asam Urat Dan High-Mobility Group Box 1 Serum Dengan Keparahan Stenosis Arteri Koroner Pasien Sindrom Koroner Akut: Tinjauan Sistematis.4(1):45-55. [View at Publisher] [Google Scholar]
Verdoia M, Khedi E, Ceccon C, Suryapranata H, De Luca GJIJoC. Duration of Dual Antiplatelet Therapy and Outcome in Patients with Acute Coronary Syndrome Undergoing Percutaneous Revascularization: A Meta-Analysis of 11 Randomized Trials. 2018;26430-8. [View at Publisher] [Google Scholar]
Chowdhury R. Association of Coronary Artery Disease Severity with Left Ventricular Dysfunction. European Journal of Preventive Cardiology. 2020;27(14):1521-30. [View at Publisher] [Google Scholar]
Chen Y. Multivessel Coronary Artery Disease and Left Ventricular Dysfunction: A Systematic Review and Meta-Analysis. Heart. 2023;109(12):910-8. [View at Publisher] [Google Scholar]
Gao Z. Meta-Analysis of Left Ventricular Remodeling in Multivessel Coronary Artery Disease. International Journal of Cardiology. 2022;35320-7. [View at Publisher] [Google Scholar]
Htay T. Left Ventricular Ejection Fraction and Outcomes in Asian Patients with Coronary Artery Disease. Asian Cardiovascular & Thoracic Annals. 2021;29(6):455-63. [View at Publisher] [Google Scholar]
Tamis-Holland JE. Contemporary Management of Multivessel Coronary Artery Disease. Journal of the American College of Cardiology. 2022;79(9):927-46. [View at Publisher] [Google Scholar]
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Arfiyan Sukmadi, Haryati
This work is licensed under a Creative Commons Attribution 4.0 International License.
