Efektivitas Herbal Sebagai Alternatif Terapi Sindrom Ovarium Polikistik (PCOS): Literatur Review
DOI:
https://doi.org/10.56742/nchat.v5i2.153Keywords:
Herbal, PCOS, Sindrom, TerapiAbstract
Menurut World Health Organization (2025), sekitar 6–13% perempuan usia reproduksi mengalami PCOS, dengan peningkatan 10–15% akibat gaya hidup tidak sehat dan obesitas. Penelitian ini bertujuan menemukan terapi alternatif yang aman, efektif, dan berkelanjutan. Berdasarkan 6 artikel dari PubMed, Google Scholar, dan Science Direct (2020–2025), beberapa terapi herbal menunjukkan efek positif pada PCOS. Asparagus africanus berpotensi melalui metode docking molekuler, Tinospora cordifolia pada hewan model meningkatkan hormon normal, sensitivitas insulin, dan struktur ovarium, sedangkan Moringa oleifera berperan melalui efek antioksidan, modulasi hormon, perbaikan mikrobiota usus, dan peningkatan folikulogenesis. Urtica dioica dan lutein menurunkan MDA, kadar testosteron, serta meningkatkan SHBG, memperbaiki ketidakseimbangan hormon. Cinnamomum verum dosis 3 g/hari selama 12 minggu menurunkan testosteron total tanpa memengaruhi metabolisme atau progesteron luteal, dan kombinasi labu kuning, bunga matahari, wijen, serta biji rami mampu menyeimbangkan FSH dan LH. Kesimpulannya, Tinospora cordifolia dan Moringa oleifera efektif sebagai terapi PCOS, memberikan dampak positif pada aspek hormonal, metabolik, dan struktural.
References
Chaudhary HEA. The Role Of Polymorphism In Various Potential Genes On Polycystic Ovary Syndrome Susceptibility And Pathogenesis. nal Ovarian Res. 2021;14(1):1–21. [View at Publisher] [Google Scholar]
World Health Organization (WHO). Polycystic ovary syndrome. 2025. [View at Publisher]
Putri, N. A., Siregar, M. F. H., & Harahap A. Prevalensi Sindrom Ovarium Polikistik dan Faktor Risiko yang Berhubungan di Indonesia. J Kesehat Reproduksi. 2021;12(2):97–104.
Risdiyaningsih V, Kurniawati EY, Darmawati D. Faktor Risiko Terjadinya Sindrom Ovarium Polikistik (Sopk). J Ilmu Kebidanan. 2023;9(2):107–11. [Google Scholar]
Jia LY, Feng JX, Li JL, Liu FY, Xie L zhen, Luo SJ, et al. The complementary and alternative medicine for polycystic ovary syndrome: a review of clinical application and mechanism. Evidence?Based Complement Altern Med. 2021;2021(1):5555315. [View at Publisher] [Google Scholar]
Xu Y, Yang Q, Wang X. Efficacy of herbal medicine (cinnamon/fennel/ginger) for primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. J Int Med Res. 2020;48(6):0300060520936179. [View at Publisher] [Google Scholar]
Kurniawati EY, Hadisaputro S SA. Status Gizi Wanita Dengan Sindrom Ovarium Polikistik (Sopk). J Ilmu Kebidanan. 2022;8(1):69–72. [View at Publisher] [Google Scholar]
Zeng LH, Rana S, Hussain L, Asif M, Mehmood MH, Imran I, et al. Polycystic ovary syndrome: a disorder of reproductive age, its pathogenesis, and a discussion on the emerging role of herbal remedies. Front Pharmacol. 2022;13:874914. [View at Publisher] [Google Scholar]
Yuliadha A SR. Psikoneuroimunologi Depresi pada Polycystic Ovary Syndrome (PCOS). Smart Med J. 2022;5(1):38. [View at Publisher] [Google Scholar]
Shen W, Jin B, Pan Y, Han Y, You T, Zhang Z, et al. The Effects of Traditional Chinese Medicine?Associated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome. Evidence?Based Complement Altern Med. 2021;2021(1):6619597. [View at Publisher] [Google Scholar]
Wu YX, Yang XY, Hu YY, Hu XH, Zhang YL, An T, et al. Moringa oleifera leaf supplementation relieves oxidative stress and regulates intestinal flora to ameliorate polycystic ovary syndrome in letrozole-induced rats. Food Sci Nutr. 2023 Sep;11(9):5137–56. [View at Publisher] [Google Scholar]
Hadipour S, Amini L, Afshar B, Ghasemi A, Haghani H, Shahr HSA, et al. The Effects of Cinnamon on Metabolic and Hormonal Status of Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial. J Client-Centered Nurs Care. 2025 Feb;11(1):55–66. [View at Publisher] [Google Scholar]
Rani R, Sharma AK, Chitme HR. Therapeutic Effect of Tinospora cordifolia (Willd) Extracts on Letrozole-Induced Polycystic Ovarian Syndrome and its Complications in Murine Model. Clin Med Insights Endocrinol Diabetes. 2023 Jan;16. [View at Publisher] [Google Scholar]
Riaz S, Haider F, Ur-Rehman R, Zafar A. Exploring the therapeutic potential of Asparagus africanus in polycystic ovarian syndrome: a computational analysis. J Integr Bioinform. 2024 Dec;21(4). [View at Publisher] [Google Scholar]
Sharma, S. et al. Role of herbal medicines in the management of polycystic ovary syndrome: A review of clinical and pre-clinical evidence. Phyther Res. 2020;34(3):567–92. [Google Scholar]
Bandariyan E, Mogheiseh A, Ahmadi A. The effect of lutein and Urtica dioica extract on in vitro production of embryo and oxidative status in polycystic ovary syndrome in a model of mice. BMC Complement Med Ther. 2021 Dec;21(1). [View at Publisher] [Google Scholar]
Rasheed N, Ahmed A, Nosheen F, Imran A, Islam F, Noreen R, et al. Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females. Food Sci Nutr. 2023 Jun;11(6):3385–93. [View at Publisher] [Google Scholar]
Shaheen AA, Hussain KAM, Al-Safy AH. Study of the Effect of Fresh Green Asparagus officinalis L. Stems Extract and Metformin Drug on Induced Polycystic Ovary Syndrome (PCOS) in Female Albino Rats. Uttar Pradesh J Zool. 2024;45(17):607–18.[View at Publisher] [Google Scholar]
Wulandari LP, Santoso B, Purwanto B. Effect of Moringa Oleifera Leaf Extract on Oxidative Stress and Theca Cell in Polycystic Ovary Syndrome Model with Insulin Resistance. Medico-legal Updat. 2021;21(2):745. [View at Publisher] [Google Scholar]
Zeng L-H, Rana S, Hussain L, Asif M, Mehmood MH, Imran I, Younas A, Mahdy A AJFAAS. Polycystic Ovary Syndrome: Adisorder Of Reproductive Age, Its Pathogenesis, And A Discussion On The Emerging Role Of Herbal Remedies. Pharmacol. 2022; [View at Publisher] [Google Scholar]
Kwon CY, Cho IH, Park KS. Therapeutic effects and mechanisms of herbal medicines for treating polycystic ovary syndrome: A review. Front Pharmacol. 2020;11:1192. [View at Publisher] [Google Scholar]
Wahyuningtyas R, Sa’adi A. Cinnamon extract effects on insulin resistance, metabolic factors, and menstrual cyclicity of women with polycystic ovary syndrome: a systematic review and meta-analysis. F1000Research. 2021;10:523. [View at Publisher] [Google Scholar]
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Copyright (c) 2025 Reni Hariyanti, Putri Lestari, Olivia Tri Monica, Ririn Indriani
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